When you have high testosterone, your face is prone to acne. High levels of testosterone in the blood can lead to an increase in sebaceous gland activity, which produces oil. The sebaceous glands are located around hair follicles and when they become blocked, this can result in elevated bumps and acne.
some research of salivary testosterone with serum values

Low agreement between serum and salivary testosterone values has been an issue in biomedical research for many years. It is not clear why salivary and serum testosterone levels are not always correlated. Although it is important to assess the quality of a test before interpreting results, the lack of consistency between serum and salivary values can lead to problems when using these tests.

Several factors may contribute to the low agreement of serum and salivary testosterone values. First, there is a need for standardization. Secondly, salivary and serum samples contain variable levels of T.
Increased activity of sebaceous glands in the skin

Increased activity of sebaceous gland in the skin is a known cause of acne. Sebaceous glands are located in the dermis, a layer of the skin that is influenced by hormones such as androgens. In males, androgens stimulate sebaceous gland activity, which can lead to oily skin and acne.

The process of sebocyte differentiation is governed by a number of mediators, including endocrine, neural and paracrine. This is a continuous process that requires several different molecules to work in unison.
Blood clots

Researchers found that men taking prescription testosterone have a greater risk of developing blood clots, especially in the first six months. However, the risk is not necessarily permanent. The risk drops off over a year and a half. There are side effects, such as decreased libido and increased fatigue. Other concerns related to testosterone use include increased risk of heart disease and depression.

a new piece of content from the writers at Regenics can form in the veins, causing swelling, redness, and warmth. In some cases, blood clots can block a vein, resulting in a heart attack or stroke. These clots are particularly dangerous because they can block arteries leading to the brain.
Cardiovascular issues

Recent research suggests that men may be at higher risk of heart attacks, blood clots, and heart failure than women. This may be related to higher levels of testosterone in the body. If confirmed, these findings may lead to new treatments for heart disease. The researchers are currently applying for grants to conduct a follow-up study in women.

Although high testosterone can increase risk of cardiovascular problems, it is unlikely to cause serious problems. Despite this potential risk, the FDA has issued a safety warning regarding testosterone use and cardiovascular disease. It recommends that older men avoid testosterone therapy.
Skin tags

When testosterone levels are high, the result can be acne breakouts. This hormonal imbalance is most commonly found in teenagers going through puberty. High testosterone levels trigger the production of sebum, which can cause breakouts. High testosterone levels can also affect your mood. This is why you should check your hormone levels with your doctor if you are experiencing acne.

Acne is caused by clogged pores that trap dirt, bacteria, and dead skin cells. This causes the skin to become inflamed and develop the reddish bumps that are characteristic of acne. In Testosterone Therapy blog article from Regenics , too much testosterone can lead to hypertension and other cardiovascular risks.

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